Regional or local hyperthermia aims to increase the temp of the tumor’s area (or if possible the tumor itself) to kill it directly with heat or sensitize it to other anti-tumor agents without damaging surrounding tissue. Some devices for this use microwave, radio frequency, ultrasound energy, or magnetic hyperthermia; each has a different method to raise the temp of the area or tumor, from direct application to a surface tumor (superficial or deep-tissue hyperthermia) to the use of needles or probes (interstitial hyperthermia). To improve efficacy of chemo for peritoneal carcinomatosis, where the intestinal lining and the whole abdomen is cancer-riddled, the chemotherapy itself is heated and directly injected into the abdominal cavity during surgery or through a percutaneous catheter.
This is called hyperthermic peritoneal perfusion (CHPP) or hyperthermicintraperitoneal chemotherapy (HIPEC).
Because only a region or a tumor is the target, higher temps (under 44°C) can be achieved, in comparison to the under 42°C limit in whole-body treatment. Again, rise of temp and time of exposure are vital, but in this modality, there is practically no chance of severe side effects.
Radiofrequency Ablation is the most common hyperthermia utilized today, radiofrequency ablation (RFA), uses completely localized, very high temps.
The innovator Harry H. LeVeen strongly endorsed this method; he did research with superheated ultrasound waves in animals, eradicating tumors altogether without damaging surrounding tissue.
With RFA we can treat tumors that can’t be surgically removed due to location or poor health. RFA isn’t cheap, but it’s affordable compared to new drugs; it also can be an outpatient procedure and can be used in conjunction with radiation, chemo, surgery, and alternative agents.